Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry

We report the design, synthesis, and biological evaluation of a new series of HDAC1 inhibitors using clickchemistry. Compound 17 bearing a phenyl ring at meta-position was identified to show much betterselectivity for HDAC1 over HDAC7 than SAHA. The compond 17 also showed better in vitro anticanceractivities against several cancer cell lines than that of SAHA. This w..